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What are the signs a horse has PPID?

Signs of PPID vary widely and may be mild or severe. Often early clinical signs can go unrecognized. Below is a check list of both early and advanced signs of PPID. If you notice any of these signs in your horse, check with your veterinarian.

Has your horse exhibited any of these unusual signs?

  • Decreased athletic performance and/or lethargy
  • Delayed shedding/decreased shedding
  • Weight loss
  • Cresty neck/fat pads around tail head/swollen sheath
  • Excessive thirst
  • Excessive urination
  • Abnormal (increased or decreased) sweating
  • Loss of muscle mass
  • Laminitis
  • Recurrent infections

What breeds are most prone to developing PPID?

PPID is seen in all breeds of horses including ponies. It also affects both male and female horses.

What age is PPID usually seen?

PPID affects horses of all ages but has been seen in horses as young as 5 years of age.2,3

How is PPID diagnosed?

Your veterinarian will examine your horse and determine if your horse should be tested for PPID. A blood test is often performed to determine if your horse is positive for the disease.

What is the treatment for PPID?

Pergolide is considered the gold standard for treatment of PPID. Prascend® (pergolide tablets) is the only FDA-approved formulation of pergolide for use in horses.

Is there a cure?

No. There is currently no cure for PPID. It is a chronic, lifelong disease that requires daily medical treatment. However, treatment with PRASCEND can reduce clinical signs of the disease, improving the quality of life for the affected horse.

Important safety information

PRASCEND is for use in horses only. Treatment with PRASCEND may cause loss of appetite. Most cases are mild. Weight loss, lack of energy, and behavioral changes also may be observed. If severe, a temporary dose reduction may be necessary. PRASCEND has not been evaluated in breeding, pregnant, or lactating horses and may interfere with reproductive hormones in these horses. PRASCEND Tablets should not be crushed due to the potential for increased human exposure. Refer to package insert for complete product information.


1. McGowan TW, Hodgson DR, McGowan CM. The prevalence of equine Cushing's syndrome in aged horses. In: Proceedings from the 25th American College of Veterinary Internal Medicine Forum; June 6-9, 2007; Seattle, WA. Abstract 603.
2. Donaldson MT, McDonnell SM, Schanbacher BJ, Lamb SV, McFarlane D, Beech J. Variation in plasma adrenocorticotropic hormone concentration and dexamethasone suppression test results with season, age, and sex in healthy ponies and horses. J Vet Intern Med. 2005;19(2):217-222.
3. Grubbs ST, Neal DL and TJ Keefe. Clinical signs associated with PPID status in a large population of horses. J Vet Intern Med 2015;29:1242