In a large, multi-site field efficacy study approved by the FDA, PRASCEND was effective in controlling clinical signs associated with PPID in horses and ponies.
Efficacy study parameters
One hundred thirteen male and female horses and ponies representing 16 different breeds in locations throughout the US were evaluated in the field trial. The horses were either privately or university-owned. Horses were aged 10 to 35 years and weighed 302 lb to 1,370 lb. All the study horses had been diagnosed with PPID prior to starting treatment with PRASCEND.
All horses received pergolide once daily for 180 days. Because of the progressive, life-threatening nature of unmanaged PPID, an untreated control group was not included in this study.
Horses were given PRASCEND tablets containing 1.0 mg of pergolide mesylate in each tablet. The target starting dose for each animal was 2 mcg of PRASCEND per kg of body weight. If endocrine test results remained abnormal at study Day 90, the target dose was increased to 4 mcg/kg.
The target oral regimen of 2 to 4 mcg/kg given once daily was selected for use in the PRASCEND clinical trial based on a review of responses to various doses of pergolide reported in the scientific literature in past years. Most recent reports have used an oral daily dose of approximately 2 mcg/kg.3,4
For complete PRASCEND dosage and administration information, click here.
Efficacy study results1,2
Investigators determined that 76% (86 of 113 horses) were treatment successes based on endocrinologic testing results and/or clinical scores. As seen in Table 1, horses showed improvement in clinical signs within 3 months and further benefits of treatment after 6 months. Hirsutism, the shaggy hair coat considered to be a key indicator of PPID, improved in an impressive 89% of treated horses.
Each of the treatment successes (n=86) showed the following results within 180 days:
- ACTH test results returned to normal or decreased by at least 50%
- DST returned to normal (<1 mcg cortisol per dL) on Day 180
- Improvement in at least one clinical sign
- No worsening in any clinical signs or development of new signs
All clinical signs evaluated showed improvement within 3 months and continued results after 6 months
|Clinical signs||Percent of horses showing improvement|
|90 days||180 days|
Total clinical scores were reduced by nearly 70%
|Clinical signs||# Cases||Cases (%)|
|Abnormal weight loss||11||9.0|
|*Three new cases and 7 pre-existing, recurring cases|
Benefits you can see
Click here to see photos showing the improvement in hair coat and body condition score before and after PRASCEND treatment.